Age-related cognitive impairment is associated with low serum concentrations of testosterone and CSF levels of amyloid beta 42 in male cynomolgus monkeys (Macaca fascicularis)
Research output: Contribution to journal › Journal article › Research › peer-review
Aged memory-impaired cynomolgus monkeys had significantly lower levels of cerebrospinal amyloid (Aβ42) and serum testosterone compared with young animals and non–memory-impaired controls. Our findings confirm similar findings in the human and substantiate the usefulness of the cynomolgus monkey as a spontaneous model for aging-associated senile dementia of the Alzheimer type.
| Original language | English |
|---|---|
| Journal | Journal of Medical Primatology |
| Volume | 50 |
| Issue number | 5 |
| Pages (from-to) | 270-272 |
| ISSN | 0047-2565 |
| DOIs | |
| Publication status | Published - 2021 |
- aging, animal model, cognitive, non-human primates, sex hormone
Research areas
ID: 280289974