Antidepressant Fluoxetine Does Not Appear to Interfere With Key Translational Parameters in the Rat Adjuvant-induced Arthritis Model
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BACKGROUND/AIM: This study aimed to investigate the analgesic effects of fluoxetine on Lewis rats of both sexes in the adjuvant-induced arthritis (AIA) rat model. In humans, chronic pain syndromes typical of rheumatoid arthritis (RA) co-exist with depression which is often treated with fluoxetine antidepressant known to have antinociceptive effects. MATERIALS AND METHODS: The experiment was terminated on day 26, after seven days of oral treatment (days 19-25) with fluoxetine and indomethacin. The effects of treatments were assessed on the final day of the study through measuring body weight, serum concentrations of a1-acid glycoprotein, visual arthritis assessment and post mortem histopathology assessment. RESULTS: Statistically significant difference was determined in the body weight of male subjects, with indomethacin-treated animals putting on significantly more weight than the vehicle and fluoxetine-treated counterparts. No differences were found between the different treatment groups in other study assessments. CONCLUSION: The present study did not provide support for analgesic effects of fluoxetine aimed at reducing the severity of the AIA model.
Original language | English |
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Journal | In Vivo |
Volume | 36 |
Issue number | 2 |
Pages (from-to) | 635-642 |
ISSN | 0258-851X |
DOIs | |
Publication status | Published - 2022 |
Bibliographical note
Publisher Copyright:
Copyright © 2022, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
- analgesia, fluoxetine, rat model, Rheumatoid arthritis
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